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Application Notes: (2R,3R)- 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol Methanesulfonate is a useful synthetic intermediate in the synthesis of Efinaconazole (E435070), a topical antifungal for onychomycosis. (2R,3R)- 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol Methanesulfonate is also used as a reagent in the synthesis of Ravuconazole (R128000), an ergosterol biosynthesis inhibitor and antifungal. /// References: Sugiura, K., et. al.: Antimicrob. Agents CH., 58, 3837 (2014)| Pesti, J., et al.: Org. Process Res. Dev., 13, 716 (2009)| Fung-Tomc., J.C., et al.: Antimicrob. Agents Chemother., 42, 313 (1988)| Tsuruoka, A., et al.: Chem. Pharm. Bull., 46, 623 (1998)| Gupta, A.K., et al.: J. Eur. Acad. Dermatol. Venereol., 19, 437 (2005)