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Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: N-Desmethyl Cyproheptadine is a metabolite of Cyproheptadine (C989200, HCl,H2O), a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Also a 5-HT2/5-HT1C serotonin receptor antagonist, H1 histamine receptor antagonist, and antipruritic. /// References: Zhang, D., et al.: Xenobiotica, 27, 301 (1997)| Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006)| de-Benedictis, F., et al.: Allergy, 63, 1395 (2008)| Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009)| Yu, C., et al.: Talanta, 2011, 83, 1376 (2011)