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Beschreibung

Category: Carbohydrates and Derivatives, Isotope Labelled Compounds, Nucleotides, Bases and Related Reagents, Sulfur and Selenium Compounds /// Appearance: White to Off-White Solid /// Application Notes: Labelled 5'-Deoxy-5'-(methylthio)adenosine (D242600). 5?-Deoxy-5?-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5?-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5?-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN). /// References: Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010)