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Application Notes: N-Debenzoyl-N-[(3E)-hex-3-enoyl] Paclitaxel is an impurity of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. /// References: Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984)| Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984)| Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995)| Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002)| Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004)