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Category: Chiral Reagents, Pharmaceuticals, Intermediates and Fine Chemicals, Steroids /// Appearance: White to Off-White Solid /// Application Notes: Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.Solubility: 1mg of Cyclopamine dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.)Solubility: 4mg of Cyclopamine dissolves in 1ml 95% Ethanol /// References: Kanda, S., et al.: J. Biol. Chem., 278,10, 8244 (2003), Rao, et al.: Development, 130, 1549 (2003), Taipale, J., et al. Nature 406, 1005 (2000), Perron, M., et al. Development 130, 1565 (2003), Watkins, D.N., et al.: Nature, 422, 313 (2003)