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Beschreibung

Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Tyrosine Kinase Inhibitors /// Appearance: White to Off-White Solid /// Application Notes: Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. Crenolanib (CP-868569) inhibits the activity of PDGFRalpha D842V kinase and prevented the phosphorylation of wild type PDGFRalpha. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation. /// References: Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010)| Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009)|