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Category: Aromatics, Heterocycles, Intermediates, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant (R517800), an antiobesity agent. /// References: Kang, S.Y. et al.: Bioorg. Med. Chem. Lett., 18, 2385 (2008)| Fulp, A. et al.: Bioorg. Med. Chem. Lett., 21, 5711 (2011)| Bergstrom, M.A. et al.: Drug Metab. and Dispos., 39, 1823 (2011)|