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Beschreibung

Category: Aliphatics, Metabolites and Impurities, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Clear Colorless Oil /// Application Notes: (2Z)-1-Chloro-6,6-dimethyl-2-hepten-4-yne is a byproduct in the synthesis of Terbinafine Hydrochloride (T107500), an orally active, antimycotic allylamine related to Naftifine. It is a specific inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Also antifungal. /// References: Kazakov, P.V., et al.: Pharm. Chem. J., 40, 452 (2006)| Petranyi, G., et al.: Science, 224, 1239 (1984)| Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985)| Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999)