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Application Notes: N-[4-Chloro-2-(2-chlorobenzoyl)?phenyl]?-2-[(2-hydroxyethyl)?amino]?acetamide is an impurity of Cloxazolam (C587475). Cyclization of N-[4-Chloro-2-(2-chlorobenzoyl)?phenyl]?-2-[(2-hydroxyethyl)?amino]?acetamide can produce Cloxazolam. Cloxazolam is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. Cloxazolam is metabolized into the active metabolite Delorezepam (D230675). /// References: Ji, M., et al. Zhongguo Yaoke Daxue Xuebao, 25, 69 (1994)| Oliveira-Silva, D. et al.: Biomed. Chrom., 23, 1266 (2009)| Kamioka, T. et al.: Psychopharmacol., 52, 17 (1977)| Fischer-Cornelssen, K.A. et al.: Arzneim.-Forsch., 31, 1757 (1981)|