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Beschreibung

Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Yellow Solid /// Application Notes: A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3beta activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder. /// References: Aardema, M., et al.: Mutat. Res., 410, 3