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Application Notes: Cetirizine 1-[(4-Chlorophenyl)phenylmethyl]piperazine Amide-d8 is labelled Cetirizine 1-[(4-Chlorophenyl)phenylmethyl]piperazine Amide (C281155) which is a possible impurity of Cetirizine (C281100), a nonsedating type histamine H1-receptor antagonist. Cetirizine is a major metabolite of Hydroxyzine. /// References: De Vos, C., et al.: Ann. Allergy, 59, 278 (1987)| Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987)| Fadel, R., et al.: Clin. Allergy, 17, 373 (1987)| Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)