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Category: Apoptosis, Pharmaceuticals, Intermediates and Fine Chemicals, Protein Kinase Inhibitors and Activators, /// Appearance: Pale Yellow to Tan Solid /// Application Notes: CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers. /// References: Hughes, D.T. et al.: Cancer Invest., 26, 118 (2008)| Place, A.E. et al.: Clin. Cancer Res., 9, 2798 (2003)| Samudio, I. et al.: J. Biol. Chem., 280, 36273 (2005)|