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Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Light Yellow Solid /// Application Notes: (S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents. /// References: Sun, H. et al.: Bioorg. Med. Chem., 21, 856 (2013)| Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010)| Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009)| Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006)| Yamahara, J. et al.: Chem. Pharm. Bull., 24, 1909 (1976)