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Application Notes: 3'-Bromo-4'-methylacetophenone is used as a starting material in the synthesis of mansonone E which is used to make mansonone E dervivatives. These derivatives are potent inhibitors of topoisomerase II (Topo II) and topoisomerase I (Topo I) and are also potent antitumor agents. 3'-Bromo-4'-methylacetophenone is also used as a reagent in the synthesis of BAF312, Siponimod which has been tested in the treatment of patients suffering from relapsing-remitting multiple sclerosis. /// References: Fang, X., et al.: J. Chem. Res., 38, 137 (2014)| Huang, Z., et al.: Eur. J. Med. Chem., 68, 58 (2013)| Pan, S., et al.: ACS Med. Chem. Lett., 4, 333 (2013)