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Category: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Pale Yellow Low Melting Solid /// Application Notes: (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma. /// References: Chen, L., et al.: Tetrahedron Lett., 58, 1644 (2017)| Ju, X., et al.: Org. Process Res. Dev., 18, 827 (2014)