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Application Notes: N-Boc-3-hydroxy-L-valine is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir (B674500), an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection. /// References: Arico-Muendel, C.C., et al.: Drug Metab. Dispos., 41, 814 (2013)| Venkatraman, S., et al.: J. Med. Chem., 49, 6074 (2006)