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Category: Aromatics, Intermediates, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Clear Light Yellow Oil /// Application Notes: 3,4-Bis(difluoromethoxy)benzaldehyde is an impurity of the antiasthmatic drug Roflumilast (R639700). 3,4-Bis(difluoromethoxy)benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders. /// References: Bender, A., et al.: Pharmacol. Rev., 58, 488 (2006), Huang, Z., et al.: Curr. Med. Chem., 13, 3253 (2006), Lerner, A., et al.: Biochem. J., 393, 21 (2006)