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Beschreibung

Category: Agonist, Anti-virals, Apoptosis, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White to Off-White Solid /// Application Notes: Betulinic Acid-d3 is the isotope labelled analog of Betulinic Acid (B330250), a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity. /// References: Pisha, E. et al.: Nat. Med., 1, 1046 (1995)| Fulda, S. et al.: Cancer Res., 57, 4956 (1997)| Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996)| Genet, C. et al.: J. Med. Chem., 53, 178 (2010)