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Category: Agonist, Anti-virals, Apoptosis, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: Betulin-d3 is the isotope labelled analog of Betulin (B330240), a derivative of Betulinic Acid (B330250) which is a compound used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity /// References: Cichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003)| Pisha, E. et al.: Nat. Med., 1, 1046 (1995)| Fulda, S. et al.: Cancer Res., 57, 4956 (1997)| Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996)| Genet, C. et al.: J. Med. Chem., 53, 178 (2010)