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Category: Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Yellow Solid /// Application Notes: Berberine Hydrochloride-d6 is labelled Berberine Hydrochloride (B318150), an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells /// References: Zhang, X. et al.: Cancer Res., 70, 9895 (2010)| Lin, H.L. et al.: Cancer 85, 1937(1999)| Schumacher, M.A. et al.: Science, 294, 2158 (2001)| Fukuda, K. et al.: J. Ethno., 66, 227(1999)|