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Category: Aromatics, Heterocycles, Mutagenesis Research Chemicals /// Appearance: Pale Yellow to Yellow Solid /// Application Notes: Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway. Benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental pollution, induces esophageal carcinogenesis. /// References: Cavalieri, E., et al.: Biochem. Pharmacol., 1988, 37, 2173 (1988)| Conney, A., et al.: Cancer Res., 42, 4875 (1982)| Penning, T., et al.: Chem. Res. Toxicol., 9, 84 (1996)| Lu, D., et al.: Chem. Res. Toxicol., 2011, 24, 1905 (2011)|