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Category: Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide-d3 is the isotope labelled analog of (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide (B203535), a byproduct formed in the preparation of Tadalafil (T004500) which is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction. /// References: Crasto, A.M., et al.: PCT Int. Appl. WO 2007110734 A1 20071004. Oct 4, 2007| Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003)| Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005)| Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)