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Category: Aromatics, Isotope Labelled Compounds, Metabolites and Impurities, Mutagenesis Research Chemicals Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Pale yellow Solid /// Application Notes: Labelled Benz[a]anthracen-3-ol is a derivative of the most potent carcinogenic hydrocarbon, 7,12-Dimethylbenz[a]anthracene (D464500), a highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction. Benz[a]anthracen-3-ol is used in carcinogenesis studies relating to breast cancer. /// References: Harvey, R. et al.: J. Org. Chem., 69, 2024 (2004)| Harvey, R. et a|.: J. Med. Chem., 31, 154 (1988)| Lee. H. et al.: J. Org. Chem., 51, 3501 (1986)| Huggins, C., et al.: Proc. Nat. Acad. Sci. U.S.A., 58, 2253 (1967), Dipple, A., et al.: N. Cancer Res., 43, 4123 (1983)|