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Beschreibung

Category: Chiral Reagents, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: Light Brown Solid /// Application Notes: Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-gamma (PPARgamma), its apoptotic effects in malignant cells have been shown to occur independently of PPARgamma. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. /// References: Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012)| Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012)| Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011)|