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Beschreibung

Category: Chiral Reagents, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates and Fine Chemicals, Pfizer compounds /// Application Notes: Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. /// References: Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993)| Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996)| Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)