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Category: Amines, Aromatics, Chiral Reagents, Intermediates, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. /// References: Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010)| Kim, D., et al.: J. Med. Chem. 48, 141 (2005)| Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005)|