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Category: Amino Acids and Derivatives, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates and Fine Chemicals /// Application Notes: Aminopterin-alpha-hyrazide, is derivative of Aminopterin (A628850), which is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity. /// References: Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998)