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Category: Aromatics, Enzyme substrates, Heterocycles, Inhibitors /// Application Notes: 2-(4-Aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxypheny Tl)-3-isoquinolinecarboxylic Acid Dihydrochloride, is a selective substrate for cytochrome P450 3A5 (CYP3A5). These compounds are also 4-Aryl-1-isoquinolinone Derivatives, which are shown to be novel, potent, and selective Phosphodiesterase 5 (PDE5) Inhibitors. /// References: Song, X., et al.: Bio. Med. Chem. Lett., 22, 1611(2012)| Tatsuzo, U., et al.: J. Med. Chem., 44, 2204 (2001)|