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Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Application Notes: MS 436 is a potent bromodomain inhibitor, binding to BRD4 and more tightly to subdomain BD1 than BD2. These domains play a key role in inflammatory gene expression, mitosis and viral/host interaction. Applications involving innhibition of bromodomains include decrease in cell proliferation for leukemia and destruction of tumor cells. /// References: Gallenkamp, D. et al.: ChemMedChem, 9, 438 (2014)| Zhang, G. et al.: J. med. Chem., 56, 9251 (2013)|