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Beschreibung

Category: Amines, Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Appearance: White Solid /// Application Notes: 4-(2-Aminoethyl)benzenesulfonamide is used as the starting material in the synthesis of Des(5-methylpyrazinecarbonyl) trans-4-Methyl Glipizide (D292605), a degradation product of Glimepiride (G410150) which is a sulfonylurea hypoglycemic agent and an antidiabetic. 4-(2-Aminoethyl)benzenesulfonamide is also used as a reagent in the synthesis of deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. /// References: Ratheiser, K., et al.: Arzneim.-Forsch., 43, 856, (1993)| Bansal, G., et al.: J. Pharmaceut. Biomed., 43, 788 (2008)| Reker, D., et al.: Angew. Chem. Int. Edit., 53, 7079 (2014)