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Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates and Fine Chemicals, Sulfur and Selenium Compounds /// Application Notes: 2-Amino-5-chlorobenzenesulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). /// References: Cannazza, G., et. al.: Bioorg. Med. Chem. Lett., 19, 1254 (2009)| Zivkovic, et al.: J. Pharmacol. Exp. Ther., 272, 300 (1995)| Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999)| Sun, Y., et al.: Nature, 417, 245 (2002)| Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)