Zurück zu Ihrem Suchergebnis

Beschreibung

Category: Amines, Aromatics, Inhibitors, Isotope Labelled Compound, Pharmaceuticals, Intermediates and Fine Chemicals /// Appearance: White Solid /// Application Notes: N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester-d3 is the labelled analog of a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-target activity and tumor growth inhibition activity. /// References: Witter, D.J., et al.: Bioorg. Medn. Chem. Letters., 18, 726 (2008)|