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Beschreibung

"Mercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to human health. Researchers are investigating the role of Hg2+-induced oxidative stress, via peroxynitrite (ONOO?) level upregulation, in the pathogenic mechanisms of mercury toxicity. BioTracker NIR-HO Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and visualization of Hg2+-induced ONOO? generation in vitro and in vivo. This fluorescent probe was designed with a ""dual-key-and-lock"" strategy where emission can only be switched on in the presence of both Hg2+ and ONOO? (1). It provides an effective method for detecting and imaging Hg2+ and ONOO- in oxidative stress studies and in the development of detoxifying drugs. Spectral PropertiesExcitation: 550 nmEmission: 680 nmReference:1. Yang, Xiaopeng, et al. ""Imaging Hg2+-induced oxidative stress by NIR molecular probe with ""dual-key-and-lock"" strategy."" Analytical Chemistry 92.17 (2020): 12002-12009."