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Beschreibung

SARS-CoV-2 belongs to Coronaviridae (CoVs) - a large family of viruses that usually cause mild to moderate upper-respiratory tract diseases. CoVs are single-stranded RNA viruses. They have a high mutation rate and are therefore highly diverse. Their hosts include human and non-human mammals, as well as birds. This product is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 25 kDa (amino acids 319- 541) and includes a C-terminal polyhistidine tag. The DTT-reduced protein migrates as a ~35 kDa polypeptide on SDS-PAGE because of glycosylation. This protein is produced in human cells, without the use of serum. The human cells expression system allows human like glycosylation and folding, and often supports higher specific binding of the protein. This Spike protein RBD is labeled with biotin, to form biotin-tagged protein. This Spike protein RBD biotin-tagged may serve as a useful tool for binding experiments while detecting protein:protein interaction assays using binding partners such as ACE2. The degree of biotinylation is >=90%. This Spike protein RBD-biotin can be visualized with streptavidin-conjugated probes (e.g., Streptavidin-HRP conjugate).