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Beschreibung

Pancreatic differentiation protein 2 (UniProt: Q8N7H5, also known as RNA polymerase II-associated factor 1 homolog, PD2, hPAF1) is encoded by the PAF1 (also known as PD2) gene (Gene ID: 54623) in human. PD2 is a nuclear protein that serves as a subunit of the RNA polymerase II associated factor (PAF) complex. It has multiple functions during transcription by RNA polymerase II. It has been implicated in regulation of development and maintenance of embryonic stem cell pluripotency. It associates with RNA polymerase II through interaction with POLR2A C-terminal domain non-phosphorylated and serine 2 and serine 5 phosphorylated forms. It is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Three isoforms of PD2 have been described that are produced by alternative splicing. PD2 has oncogenic property and is shown to be overexpressed in pancreatic cancer cells. In normal murine pancreas, its expression is restricted to acinar cells, however, its expression is increased in the ductal cells of mouse model of pancreatic cancer with advancing age. (Ref.: Dey, P., et al (2014). Oncotarget, 5(12), 4480-4491).