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Beschreibung

Cathepsin G (EC 3.4.21.20, UniProt P08311, also known as CatG, CG) is encoded by the CTSG gene (Gene ID 1511) in human. Cathepsin G is a peptidase S1 protein family protease found in azurophil granules of neutrophilic polymorphonuclear leukocytes. Cathepsin G displays a substrate specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G is involved in connective tissue remodeling at sites of inflammation. Cathepsin G is also a component of neutrophil extracellular traps (NETs) composed of ejected lattice of chromatin enmeshed with granular and nuclear proteins, including histones, calprotectin and cathepsin G, that are capable of capturing and killing microbial invaders. Antibodies raised against cathepsin G or histones have been shown to limit the bactericidal capacity of NETs towards pathogens. Cathepsin G is prouduced with a signal peptide (a.a. 1-18) and a propeptide sequence (a.a. 19-20) that are removed posttranslationally to yield the mature (a.a. 21-255) enzyme.