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Beschreibung

Gamma-aminobutyric acid receptor-associated protein (UniProt: O95166, also known as GABA(A) receptor-associated protein, MM46) is encoded by the GABARAP (also known as FLC3B, HT004) gene (Gene ID: 11337) in human. GABARAP, is a member of the highly conserved family of mammalian autophagy-related 8 protein (ATG8), is implicated in a variety of intracellular transport processes and in autophagy where it is involved in late stage autophagosome maturation. Like other ATG8s, GABARAP can also undergo lipidation by a ubiquitin-like conjugation system, which then promotes its association to autophagosomal membranes. The precursor form of human GABARAP is processed by ATG4 to expose the C-terminal glycine to generate the cytosolic form GABARAP-I, which is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to produce the membrane-bound GABARAP-II form. Under nutrient rich conditions, GABARAP is reported to accumulate in the pericentriolar material from which it can be translocated to forming autophagosomes during starvation. Its expressed is observed in heart, brain, placenta, liver, skeletal muscle, kidney, and pancreas. It is also reported to serve as a ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors. Clone 8H5 recognizes an epitope in the N-terminal region and exhibits high specificity for GABARAP without any cross-reactivity for GABARAPL1, -L2 or LC3. (Ref.: Simons, IM., et al. (2019). Sci. Rep. 9, 256, Kabeya, Y., et al. (2004). J. Cell Sci. 117(13), 2805-2812).