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Beschreibung

Natural cytotoxicity triggering receptor 3 (UniProt: O14931, also known as Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337) is encoded by the NCR3 (also known as 1C7, LY117) gene (Gene ID: 259197) in human. NKp30 is a single-pass type I membrane protein that is selectively expressed by all resting and activated NK cells. Its weaker expression is observed in spleen. It serves as a receptor of natural killer/NK cell. It is activated by binding of extracellular ligands including BAG6 and NCR3LG1. It stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It cooperates with NKp46 and/or NKp44 in inducing NK-mediated cytotoxicity against the majority of target cells. It is also reported to control NK cells cytotoxicity against tumor cells. Its interaction with BAG6 promotes myeloid dendritic cells (DC) maturation, both through killing DCs that fail to achieve a mature phenotype and by inducing the release of TNF-alpha and interferon-gamma by NK cells that promote DC maturation. NKp30 is synthesized with a signal peptide (aa 1-18), which is subsequently cleaved off to produce the mature protein that contains an extracellular domain (aa 19-135), a transmembrane domain (aa 136-156), and a cytoplasmic domain (aa 157-201). Six isoforms of NKp30 have been described that are produced by alternative splicing.