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Beschreibung

Microtubule organization protein AKNA (UniProt: Q7Z591, also known as AT-hook-containing transcription factor, AKNA) is encoded by the AKNA (also known as KIAA1968) gene (Gene ID: 80709) in human. AKNA is a centrosomal protein that plays a key role in cell delamination by regulating microtubule organization. It is predominantly expressed by lymphoid tissues and its higher expression is observed in the spleen, lymph nodes and peripheral blood leukocytes. Its expression is reported in B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. AKNA localizes to the distal part of the subdistal appendages of the mother centriole in interphase and is also found at the proximal ends of centrioles and along microtubules. It dissociates from centrosomes during M-phase and reassembles at the centrosomes during late telophase and early G1 phase. This dissociation and reassembly are regulated by its phosphorylation. AKNA presence is also reported in subdistal appendages of the mother centriole in specific subtypes of neural stem cells and all basal progenitors and is required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis. Eight different isoforms of AKNA have been described that are produced by alternative splicing. (Ref.: Ortega, GC., et al. (2019) Nature 567(7746), 113-117).