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Beschreibung

Endothelial cells line the interior surface of blood and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of tissue or organ. Laminin-411 is known to bind to the integrin alpha6beta1 which is located on the cell surface of pluripotent stem cells and is known to induce endothelial cell differentiation. Professor Kiyotoshi Sekiguchi's group (Matrixome, Inc.) have produced a recombinant E8 fragment of laminin-411 at large-scale while retaining the full integrin binding activity. ECMatrix-411 E8 Laminin Substrates are recombinant Laminin-411-E8 fragments which bind to integrin alpha6beta1 and increases the differnetiuation of pluripotent stem cells (ES/iPSCs) into acetyl-LDL+/ CD31+ endothelial cells.