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Beschreibung

Inhibin alpha chain (UniProt: P04087, also known as IHNA, A-inhibin subunit) is encoded by the INHA gene (Gene ID: 397386) in porcine. Inhibins are dimeric glycoproteins that are composed of an -subunit and either a betaA (inhibin A) or a betaB-subunit (inhibin B). Inhibins and activins inhibit and activate, respectively, the secretion of follicle stimulating hormone (FSH) by the pituitary gland. They are also involved in regulating a number of other functions. Inhibins are glycoprotein hormones of the TGFbeta superfamily and are composed of two subunits, an -subunit (20 kDa) and a beta-subunit (13 kDa), linked by a disulfide bridge. Two forms of inhibin have been identified, Inhibin-A and -B. Their subunits are shown to be identical, while the beta-subunit differs between both forms of inhibin and are denoted as betaA and betaB, respectively. Inhibin-A is secreted during the luteal phase, while Inhibin-B is predominantly secreted during the follicular phase. The inhibin -subunit contains an N-linked glycosylation site and this glycosylation is shown to be essential for its FSH suppressing activity. Porcine Inhibin chain is synthesized as a protein of 364 amino acids with a signal peptide (aa 1-17) and a propeptide (aa 18-60), which are subsequently cleaved off to generate Inhibin N-terminal region (aa 61-230) and the Inhibin chain (aa 231-364). Subsequent cleavage at aa 230-231 results in the production of Inhibin chain. Circulating level of Inhibins is a reliable marker for some types of ovarian cancer and is a predictor for the conditions of spermatogenesis. (Ref.: Makanji, Y., et al. (2014). Endocr. Rev. 35(5), 747-794, Bilezikjian, LM., et al. (1993). Endocrinology. 133(6), 2545-2553).