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Beschreibung

Neurexin-1 (UniProt Q9CS84, also known as Neurexin I-alpha, Neurexin-1-alpha) is encoded by the Nrxn1 (also known as Kiaa0578) gene (Gene ID 18189) in murine species. Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Mutations in the genes encoding for neurexins are implicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, alpha-NRXNs and beta-NRXNs. The alpha-NRXNs are larger and have different amino-terminal extracellular sequences than beta-NRXNs. beta-NRXNs act as receptors for neuroligin and have been found to play a role in angiogenesis.