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Beschreibung

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3beta (IC50 >60 µ,M). Shown to mimic the effect of Wnt and induce beta-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.

Strukturformel

SAF-681664-2MG

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