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Beschreibung

A potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM, IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µ,M. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson's disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type., An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µ,M, IC50 = 0.88 µ,M) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µ,M. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson's disease, and other neurological disorders. Permeability may vary from cell type to cell type.