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Beschreibung

A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µ,M in a viability assay using U87-MG and U373-MG, respectively, no inhibition against nontumor NHA at 10 µ,M) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo., A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µ,M in a viability assay using U87-MG and U373-MG, respectively, no inhibition against nontumor NHA at 10 µ,M) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo. Also available in InSolution format (Cat. No. 573129.