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Beschreibung

A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µ,M). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µ,M). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µ,M) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µ,M). Exhibits anti-leishmanial effects., A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µ,M) by forming a stable complex. At higher concentrations (~110 µ,M), it inhibits SHP-2 and PTP1B activities.