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Beschreibung

A potent, cell-permeable, and reversible inhibitor of beta-secretase that corresponds to the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Abetatotal (IC50 = 700 nM) and Abeta1-42 (IC50 = 2.5 µ,M) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751., A potent, cell-permeable, and reversible inhibitor of beta-secretase. Corresponds to the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Abetatotal (IC50 = 700 nM) and Abeta1-42 (IC50 = 2.5 µ,M) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.