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Beschreibung

A cell-permeable and reversible inhibitor of protein kinase C delta (PKCdelta, IC50 = 3-6 µ,M) and PKCΘ, isozymes. Also inhibits PKCalpha, PKCbeta, and PKCgamma isoforms, but with significantly reduced potency (IC50 = 30-42 µ,M). Has reduced inhibitory activity on PKCepsilon, PKCeta, and PKCξ, (IC50 = 80-100 µ,M). Also known to inhibit CaM kinase III (IC50 = 5.3 µ,M)., A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCdelta (IC50 = 3-6 µ,M) and PKCtheta. Inhibits the PKCalpha, PKCbeta, and PKCgamma isoforms, but with significantly reduced potency (IC50 = 30-42 µ,M). Has reduced inhibitory activity on PKCepsilon, PKCeta, and PKCzeta (IC50 = 80-100 µ,M). Also known to inhibit CaM kinase III (IC50 = 5.3 µ,M).