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Beschreibung

Cell permeable, selective competitive inhibitor of cAMP-specific phosphodiesterase IV (IC50 = 800 nM). Rolipram does not inhibit PDE I or PDE II, even at concentrations as high as 100 µ,M. It is only a weak inhibitor of PDE III (IC50 = 100 µ,M). A rolipram-insensitive phosphodiesterase IV subtype is also known to exist., A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-kappaB and NFAT activation in Jurkat and primary T cells.