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Beschreibung

An uncharged, 1,4-di-substituted, phenyl-linked, bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, substrate competitive, active-site-directed inhibitor of protein tyrosine phosphatases (PTP). Reported to inhibit SHP-2 (IC50 = 1.8 microM), PTP1B (IC50 = 2.5 microM), PTP-&epsilon, (IC50 = 8.4 microM), PTP-Meg-2 (IC50 = 13 microM), PTP-&sigmaf, (IC50 = 20 microM), PTP-&beta, (IC50 = 6.4 microM), and PTP-micro (IC50 = 6.7 microM)., An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic that acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases (PTP, IC50 = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 microM for SHP-2, PTP1B, PTP-&epsilon,, PTP-Meg-2, PTP-&sigmaf,, PTP-&beta,, and PTP-micro, respectively).